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publications

Structure-adaptive canonical correlation analysis for microbiome multi-omics data

Published in Frontiers in Genetics, 2024

We introduce a new sCCA framework for integrating microbiome and other high-dimensional omics data, explicitly accounting for the compositional nature of microbiome data. Our method incorporates prior structural information among taxa via adaptive penalization, improving accuracy when structure is informative and remaining robust to misspecification. Extensive simulations and real data analyses show that this approach outperforms existing methods.

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Joint mirror procedure: Controlling false discovery rate for identifying simultaneous signals

Published in Biometrics, 2024

We present the joint mirror (JM) procedure for detecting features with joint statistical significance while controlling the false discovery rate (FDR) in finite samples. JM iteratively shrinks the rejection region based on updated information until the estimated false discovery proportion meets the target FDR. We further introduce the composite FDR (cFDR), which weights false discoveries by their number of null components, and prove JM’s control of cFDR using a leave-one-out technique. Our efficient algorithm accommodates partial ordering and, through simulations and real applications, demonstrates robust FDR control and improved power.

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Multiplex depth for network-valued data and applications

Published in Journal of Computational and Graphical Statistics, 2025

We introduce multiplex depth, a novel extension of Tukey’s depth for analyzing network-valued data. It enables data ordering, center estimation, and outlier detection. We establish its theoretical properties, develop efficient algorithms, and validate our method through simulations and brain network data, demonstrating improved performance on key analysis tasks.

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teaching

Probability Theory

Graduate course, Renmin University of China, Institute of Statistics and Big Data, 2020

Statistical Learning

Undergraduate course, Renmin University of China, Institute of Statistics and Big Data, 2024